Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EOMES contributors: mct/pgu - updated : 11-06-2015
HGNC name eomesodermin homolog (Xenopus laevis)
HGNC id 3372
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx    
Nervousbrainforebrain   
 brain    
Reproductivefemale systemuterus   
 male systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text
  • its expression and promotes formation of cardiovascular progenitors by directly activating the bHLH (basic-helix-loop-helix) transcription factor gene MESP1 upstream of the core cardiac transcriptional machinery
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a large N terminal DNA binding domain (T-box)
  • a carbohydrate binding domain within the Eomes C-terminal region sufficient for transfer and important for gene activation
  • HOMOLOGY
    interspecies ortholog to murine T-bet
    Homologene
    FAMILY TBR1, brachyury subfamily
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in developmental regulation
  • acting as a key regulator in the development of cell-mediated immunity
  • involved in late neuronal development
  • may helps effect a cellular response to a morphogen gradient
  • important role for TFAP2C, SMARCA4, and EOMES in trophoblast stem cell self-renewal
  • with CDX2, are regarded as the key transcription factors required for the establishment of a functional trophectoderm
  • essential for epithelial-to-mesenchymal transition, mesoderm migration and specification of definitive endoderm during gastrulation
  • controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3
  • transcription factors CDX2 and EOMES may play critical roles in induced trophoblast progenitor (iTP) cell generation
  • TBX2, TBX3, TBX4, TBX5 and three members of TBX1 (TBX1, TBX15, TBX18), Brachyury (T) and Eomes (TBR2) are expressed in the developing limb
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component forms a Complex with phosphorylated SMAD2 to activate several mesodermal genes
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with SMAD2 and is capable of working in a non-cell autonomous manner via transfer of EOMES protein between adjacent embryonic cells
  • TFAP2C directly regulated the basal progenitor fate determinants NEUROD4 and EOMES
  • interact with the transcription factor GATA3, preventing GATA3 binding to the IL5 promoter
  • IRF4 is required to suppress EOMES expression following CD8+ T-Cell activation
  • POU3F2, POU3F3 influence multiple stages of neurogenesis by suppressing Notch effector HES5, and promoting the expression of proneural transcription factors EOMES and TBR1
  • NFIL3 binds directly to the regulatory regions of both EOMES and ID2, promoting their transcription
  • EOMES coordinates neurogenesis expansion and precise microcircuit assembly via PCDH19 in the mammalian cortex
  • cell & other
    REGULATION
    activated by inhibition of ITK together with IL4 increases EOMES up-regulation
    ASSOCIATED DISORDERS
    corresponding disease(s) MPAC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    polymicrogyria
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking both transcription factors Eomesodermin (Eomes) and Tbx21 failed to develop NK cells