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FLASH GENE
Symbol ALDH4A1 contributors: - updated : 05-02-2004
HGNC name aldehyde dehydrogenase 4 family, member A1
HGNC id 406
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a putative 24 aminoacid N terminal mitochondrial targeting sequence
mono polymer homomer , dimer
isoforms Precursor targeting sequence cleaved to produced a mature monomer of 539 aminoacids
HOMOLOGY
interspecies homolog to murine Aldh4a1
Homologene
FAMILY aldehyde dehydrogenase family
CATEGORY enzyme , transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,matrix
basic FUNCTION
  • oxydoreductase
  • aldehyde dehydrogenase 4 (glutamate gamma-semialdehyde dehydrogenase; pyrroline-5-carboxylate dehydrogenase)
  • converting proline or ornithine to glutamate
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism aminoacid
    signaling
    proline metabolism and catabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NAD+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) P5CDD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS