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FLASH GENE

Symbol

ALDH4A1

contributors: - updated : 05-02-2004

HGNC name	aldehyde dehydrogenase 4 family, member A1
HGNC id	406

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Endocrine pancreas         Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a putative 24 aminoacid N terminal mitochondrial targeting sequence

mono polymer

homomer , dimer

isoforms

Precursor

targeting sequence cleaved to produced a mature monomer of 539 aminoacids

HOMOLOGY

interspecies

homolog to murine Aldh4a1

Homologene

FAMILY

aldehyde dehydrogenase family

CATEGORY

enzyme , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix

basic FUNCTION	oxydoreductase
	aldehyde dehydrogenase 4 (glutamate gamma-semialdehyde dehydrogenase; pyrroline-5-carboxylate dehydrogenase)
	converting proline or ornithine to glutamate

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

aminoacid

signaling

proline metabolism and catabolism

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	NAD+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

P5CDD

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS