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FLASH GENE

Symbol

NR2C1

contributors: mct - updated : 18-08-2011

HGNC name	nuclear receptor subfamily 2, group C, member 1
HGNC id	7971

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a central bipartite (class II) zinc finger
	a N terminal modulator domain
	a DNA binding domain
	a C terminal ligand domain with multiple ligand-binding domains

HOMOLOGY

Homologene

FAMILY	nuclear receptor subfamily 2, group C
	steroid/thyroid hormone receptor superfamily

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	orphan nuclear receptor
	NR2C1/NR2C2 directly represses GATA1 transcription in erythroid progenitor cells through an evolutionarily conserved binding site within a well-characterized, tissue-specific GATA1 enhancer
	possible roles for NR2C1 and NR2C2 in early embryonic development by regulating key genes involved in stem cell self-renewal, commitment, and differentiation
	play roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

complexing with HDAC3 through RID domains

INTERACTION

DNA

RNA

small molecule

protein

interacting with HDAC3 and HDAC4

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS