basic FUNCTION
| orphan nuclear receptor |
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NR2C1/NR2C2 directly represses GATA1 transcription in erythroid progenitor cells through an evolutionarily conserved binding site within a well-characterized, tissue-specific GATA1 enhancer |
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possible roles for NR2C1 and NR2C2 in early embryonic development by regulating key genes involved in stem cell self-renewal, commitment, and differentiation |
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play roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system |