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FLASH GENE
Symbol BICD2 contributors: mct - updated : 22-01-2019
HGNC name bicaudal D homolog 2 (Drosophila)
HGNC id 17208
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus (BICD2-N) strongly promotes stable interaction between dynein and dynactin
  • five coiled-coil domains
  • C-terminal coiled-coil domain interacts with various cargos, such as RAB6A
  • HOMOLOGY
    interspecies homolog to Drosophila bicaudal D
    intraspecies homolog to Bic D protein
    Homologene
    FAMILY
  • BicD family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • playing a role associated with cell cycle independent microtubule dynamics
  • evolutionary conserved motor-adaptor protein, is implicated in dynein-mediated transport as a molecular linker between the dynein motor and various cargos
  • cytoplasmic conserved motor-adaptor protein involved in anterograde and retrograde transport
  • has roles in the synaptic vesicle and membrane traffic and Golgi structure
  • essential in dynein-dynactin microtubule transport, in clathrin-mediated synaptic-vesicular recycling, and in the Golgi network, and crucial for the functional integrity of lower motor neurons
  • its function is essential for motor neuron physiology
  • key adaptor protein that interacts with the dynein-dynactin motor complex, which facilitates trafficking of cellular cargos that are critical to motor neuron development and maintenance
  • essential non-cell-autonomous role of BICD2 in neuronal cell migration, which might be connected to cargo trafficking pathways in glia cells
  • joins dynein with dynactin into a ternary complex (termed DDB) capable of processive movement
  • BICD2 facilitates infection by promoting the trafficking of HIV viral cores to the nucleus, thereby promoting nuclear entry of the viral genome and infection
  • highly conserved motor adaptor protein that regulates the dynein-dynactin complex in different cellular processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with NEK9
  • with GOPC and DCTN1, interacting with RAB6A (Bergrede 2009)
  • BICD2, dynactin, and PAFAH1B1 cooperate in regulating dynein recruitment to cellular structures
  • ASUN controls dynein localization via a mechanism distinct from that of either BICD2 or CENPF
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SMALED2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • transgenic mice with neuron-specific expression of Bicaudal D2 N-terminus (Bicd2-N) did not develop signs of motor neuron degeneration and motor abnormalities
  • Bicd2-deficient mice develop disrupted laminar organization of cerebral cortex and the cerebellum, pointing to impaired radial neuronal migration