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FLASH GENE
Symbol BICD2 contributors: mct - updated : 22-01-2019
HGNC name bicaudal D homolog 2 (Drosophila)
HGNC id 17208
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbraindiencephalonamygdala  
 brainhindbraincerebellum  
 braindiencephalonhypothalamus  
 braindiencephalonthalamus  
 spinal cord   highly Homo sapiens
Reproductivemale systemtestis   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus (BICD2-N) strongly promotes stable interaction between dynein and dynactin
  • five coiled-coil domains
  • C-terminal coiled-coil domain interacts with various cargos, such as RAB6A
  • HOMOLOGY
    interspecies homolog to Drosophila bicaudal D
    intraspecies homolog to Bic D protein
    Homologene
    FAMILY
  • BicD family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • playing a role associated with cell cycle independent microtubule dynamics
  • evolutionary conserved motor-adaptor protein, is implicated in dynein-mediated transport as a molecular linker between the dynein motor and various cargos
  • cytoplasmic conserved motor-adaptor protein involved in anterograde and retrograde transport
  • has roles in the synaptic vesicle and membrane traffic and Golgi structure
  • essential in dynein-dynactin microtubule transport, in clathrin-mediated synaptic-vesicular recycling, and in the Golgi network, and crucial for the functional integrity of lower motor neurons
  • its function is essential for motor neuron physiology
  • key adaptor protein that interacts with the dynein-dynactin motor complex, which facilitates trafficking of cellular cargos that are critical to motor neuron development and maintenance
  • essential non-cell-autonomous role of BICD2 in neuronal cell migration, which might be connected to cargo trafficking pathways in glia cells
  • joins dynein with dynactin into a ternary complex (termed DDB) capable of processive movement
  • BICD2 facilitates infection by promoting the trafficking of HIV viral cores to the nucleus, thereby promoting nuclear entry of the viral genome and infection
  • highly conserved motor adaptor protein that regulates the dynein-dynactin complex in different cellular processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with NEK9
  • with GOPC and DCTN1, interacting with RAB6A (Bergrede 2009)
  • BICD2, dynactin, and PAFAH1B1 cooperate in regulating dynein recruitment to cellular structures
  • ASUN controls dynein localization via a mechanism distinct from that of either BICD2 or CENPF
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SMALED2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • transgenic mice with neuron-specific expression of Bicaudal D2 N-terminus (Bicd2-N) did not develop signs of motor neuron degeneration and motor abnormalities
  • Bicd2-deficient mice develop disrupted laminar organization of cerebral cortex and the cerebellum, pointing to impaired radial neuronal migration