Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UBE4B contributors: mct - updated : 23-04-2012
HGNC name ubiquitination factor E4B (UFD2 homolog, yeast)
HGNC id 12500
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an U-box domain
    • mono polymer heteromer
    HOMOLOGY
    interspecies homolog to yeast Ufd2
    homolog to Drosophila Nosa
    homolog to murine Ube4b
    Homologene
    FAMILY
  • ubiquitin conjugation factor E4 family
    • CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in multi-ubiquitination chain assembly with E1, E2, E3
  • might play an important role in the regulation of cisplatin mediated cell death mediated by TP63
  • U box-containing protein that functions as an E3 ubiquitin ligase and an E4 polyubiquitin chain elongation factor
  • promotes TP53 polyubiquitination and degradation and inhibits TP53-dependent transactivation and apoptosis
  • negatively regulates the level of TP53 and inhibits TP53-dependent transactivation and apoptosis
  • U-box-containing ubiquitylation enzyme that promotes ubiquitin chain assembly on substrates
    • CELLULAR PROCESS cell cycle
    protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with, and thereby mediated poly-ubiquitylation of ATXN3
  • E3 and E4 ubiquitin ligase, that physically interacts with TP53 and MDM2
  • E3 and E4 ubiquitin ligase with a U-box domain, interacting physically with both TP53 and MDM2
  • TTK is a target of the UBE4B enzyme (UBE4B-mediated TTK degradation is conserved in humans and is important for mitotic progression)
    • cell & other
    REGULATION
    Other proteolytically cleaved by caspases during apoptosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    amplification and overexpression of UBE4B represent previously undescribed molecular mechanisms of inactivation of TP53 in brain tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene targeted expression of UBE4Bis a potential gene therapy for MJD
    Marker
    Therapy target
    ANIMAL & CELL MODELS