basic FUNCTION
| involved in multi-ubiquitination chain assembly with E1, E2, E3 |
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might play an important role in the regulation of cisplatin mediated cell death mediated by TP63 |
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U box-containing protein that functions as an E3 ubiquitin ligase and an E4 polyubiquitin chain elongation factor |
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promotes TP53 polyubiquitination and degradation and inhibits TP53-dependent transactivation and apoptosis |
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negatively regulates the level of TP53 and inhibits TP53-dependent transactivation and apoptosis |
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U-box-containing ubiquitylation enzyme that promotes ubiquitin chain assembly on substrates |