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FLASH GENE
Symbol FCER1A contributors: mct - updated : 26-10-2015
HGNC name Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
HGNC id 3609
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two Ig-extracellular domain, and extracellular domain of the type I transmembrane protein FCER1A plays a role in intracellular processing and expression at the cell surface
  • a short cytoplasmic tail
    • conjugated GlycoP
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies ortholog to murine Fcer1a
    homolog to rattus Fcer1a
    homolog to C.elegans T24E12.2
    Homologene
    FAMILY
  • immunoglobulin superfamily
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • playing a central role in allergic disease
  • coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma
  • counterregulation of FCER1A and TLR7 pathways exists in pDCs (Plasmacytoid dendritic cells), and IgE cross-linking impairs pDC antiviral responses
  • FCER1A on dendritic cells drives the cascade of pathogenic reactions linking the initial allergen capture by IgE with subsequent Th2-dominated T cell responses and the development of late-phase allergic tissue inflammation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with a beta chain and a homodimeric disulfide linked gamma subunit
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to IgE
  • MS4A2 acts as a critical element in mast cell synergistic degranulation response through FCER1A
  • PTPRE negatively regulates FCER1A-mediated signalling pathways and thus constitutes a novel target for ameliorating allergic conditions
  • like INPP5D, UBASH3B functions as a negative regulator of FCER1A signaling in mast cells
  • SPI1 and GATA1 transactivate FCER1A
  • DOCK5 functions as a key signaling adaptor that links FCER1A signals to microtubule dynamics during mast cell degranulation
  • SH3BP2 is a cytoplasmic adaptor protein that acts as a positive regulator in mast cell FCER1A-dependent signaling
  • functional interaction between FCER1A and ANPEP on mast cell (MC)
  • PLSCR1 aggravates anaphylactic reactions by increasing FCER1A-dependent mast cell degranulation
    • cell & other
    REGULATION
    Other regulated by RHOH in mast cells by facilitating SYK activation, possibly as an adaptor molecule for SYK (
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS