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FLASH GENE
Symbol FCER1A contributors: mct - updated : 26-10-2015
HGNC name Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
HGNC id 3609
Location 1q23.2      Physical location : 159.259.503 - 159.278.013
Synonym name
  • Fc epsilon RI alpha-chain
  • high affinity immunoglobulin epsilon receptor alpha-subunit
  • immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
  • Synonym symbol(s) FCE1A, FcERI
    DNA
    TYPE functioning gene
    STRUCTURE 18.51 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see MCL1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1191 - 257 - 2009 19124738
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine     Homo sapiens
    Reproductivemale systemprostate  highly
    Respiratorylung   moderately
    Urinarykidney   moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
     mast cell
    Digestiveepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two Ig-extracellular domain, and extracellular domain of the type I transmembrane protein FCER1A plays a role in intracellular processing and expression at the cell surface
  • a short cytoplasmic tail
  • conjugated GlycoP
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies ortholog to murine Fcer1a
    homolog to rattus Fcer1a
    homolog to C.elegans T24E12.2
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • playing a central role in allergic disease
  • coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma
  • counterregulation of FCER1A and TLR7 pathways exists in pDCs (Plasmacytoid dendritic cells), and IgE cross-linking impairs pDC antiviral responses
  • FCER1A on dendritic cells drives the cascade of pathogenic reactions linking the initial allergen capture by IgE with subsequent Th2-dominated T cell responses and the development of late-phase allergic tissue inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with a beta chain and a homodimeric disulfide linked gamma subunit
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to IgE
  • MS4A2 acts as a critical element in mast cell synergistic degranulation response through FCER1A
  • PTPRE negatively regulates FCER1A-mediated signalling pathways and thus constitutes a novel target for ameliorating allergic conditions
  • like INPP5D, UBASH3B functions as a negative regulator of FCER1A signaling in mast cells
  • SPI1 and GATA1 transactivate FCER1A
  • DOCK5 functions as a key signaling adaptor that links FCER1A signals to microtubule dynamics during mast cell degranulation
  • SH3BP2 is a cytoplasmic adaptor protein that acts as a positive regulator in mast cell FCER1A-dependent signaling
  • functional interaction between FCER1A and ANPEP on mast cell (MC)
  • PLSCR1 aggravates anaphylactic reactions by increasing FCER1A-dependent mast cell degranulation
  • cell & other
    REGULATION
    Other regulated by RHOH in mast cells by facilitating SYK activation, possibly as an adaptor molecule for SYK (
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS