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FLASH GENE
Symbol STRN contributors: mct - updated : 18-01-2011
HGNC name striatin, calmodulin binding protein
HGNC id 11424
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a caveolin -binding domain
  • a coiled-coil structure, playing an essential role in the targeting of STRN within spines, and also crucial for the homo- and hetero-oligomerization of these proteins
  • a Ca2+/calmodulin binding domain and eight (?seven) WD40 repeats in the C terminal region
    • HOMOLOGY
    interspecies homolog to murine Strn
    Homologene
    FAMILY
  • striatin family of WD-40 repeat proteins
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text cytosolic and membrane bound somatodendritic compartments
    basic FUNCTION
  • may function as scaffolding or signaling protein and may
    • play a role in dendritic Ca(2+) signaling
  • intracellular proteins, mainly expressed in neurones of the mammalian central nervous system where they are thought to be involved in vesicular traffic and Ca(2+) signalling
  • molecular scaffold required for rapid, nongenomic estrogen-mediated activation of downstream signaling pathways
  • molecular scaffold required for rapid, nongenomic estrogen-mediated activation of downstream signaling pathways
  • multimodular WD-repeat, calmodulin and calveolin-binding protein
  • PDCD10 and striatins exhibit opposing functions on the targeting of MST4 to the Golgi and Golgi positioning
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with GS2NA and protein phosphatase A heterodimer (PPP2PA/C)
  • STRIPAK contains the PPP2CA, the striatins (STRN, STRN3, STRN4), MOB4, FAM40A and FAM40B, the cerebral cavernous malformation 3 (CCM3) protein, and members of the germinal center kinase III family of Ste20 kinases
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • calmodulin binding, caveolin
  • directly binds to AAs 183-253 of ESR1, targets ESR1 to the cell membrane, and serves as a scaffold for the formation of an ESR1-Galphai complex
  • STRN, STRN32, STRN4 binds directly to PPP2CA and PDCD10
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS