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FLASH GENE

Symbol

STRN

contributors: mct - updated : 18-01-2011

HGNC name	striatin, calmodulin binding protein
HGNC id	11424

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	118.14 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

in close proximity to CALM2

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003162 18 - 3479 NP_003153 86.1 780 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain         Homo sapiens   ganglia         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal     Nervous peripherous       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a caveolin -binding domain
	a coiled-coil structure, playing an essential role in the targeting of STRN within spines, and also crucial for the homo- and hetero-oligomerization of these proteins
	a Ca2+/calmodulin binding domain and eight (?seven) WD40 repeats in the C terminal region

HOMOLOGY

interspecies

homolog to murine Strn

Homologene

FAMILY

striatin family of WD-40 repeat proteins

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
text	cytosolic and membrane bound somatodendritic compartments

basic FUNCTION	may function as scaffolding or signaling protein and may
	play a role in dendritic Ca(2+) signaling
	intracellular proteins, mainly expressed in neurones of the mammalian central nervous system where they are thought to be involved in vesicular traffic and Ca(2+) signalling
	molecular scaffold required for rapid, nongenomic estrogen-mediated activation of downstream signaling pathways
	molecular scaffold required for rapid, nongenomic estrogen-mediated activation of downstream signaling pathways
	multimodular WD-repeat, calmodulin and calveolin-binding protein
	PDCD10 and striatins exhibit opposing functions on the targeting of MST4 to the Golgi and Golgi positioning

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	forming a complex with GS2NA and protein phosphatase A heterodimer (PPP2PA/C)
	STRIPAK contains the PPP2CA, the striatins (STRN, STRN3, STRN4), MOB4, FAM40A and FAM40B, the cerebral cavernous malformation 3 (CCM3) protein, and members of the germinal center kinase III family of Ste20 kinases

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	calmodulin binding, caveolin
	directly binds to AAs 183-253 of ESR1, targets ESR1 to the cell membrane, and serves as a scaffold for the formation of an ESR1-Galphai complex
	STRN, STRN32, STRN4 binds directly to PPP2CA and PDCD10

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS