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FLASH GENE
Symbol JAG2 contributors: mct/pgu - updated : 19-05-2021
HGNC name jagged 2
HGNC id 6189
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a DSL (Delta, Serrate, Lag2) domain
  • 16 EGF-like repeats
  • a cysteine-rich extracellular region
  • isoforms Precursor
    HOMOLOGY
    interspecies homolog to rattus Jag2
    homolog to Drosophila serrate Dress30
    homolog to murine
    Homologene
    FAMILY Notch ligand family
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • overexpression may be an early event in the pathogenesis of multiple myeloma involving IL6 production
  • play dual roles as activators of Notch receptor signaling and as receptors that mediate nuclear signaling events via gamma-secretase-generated cytoplasmic domain
  • critical role for JAG2-Notch signaling in the maintenance of proliferating neural precursors in a discrete compartment of the neural tube during the continuing growth and development of the vertebrate nervous system
  • JAG2-Notch axis plays a crucial role in dendritic cells-mediated NK cell cytotoxicity
  • can regulate the expression of cytokines that can promote antitumor immunity
  • its expression by dendritic cells is not sufficient or required for Th2 cell differentiation
  • IRF6 and the Notch ligand JAG2 function in convergent molecular pathways during oral epithelial differentiation
  • like Delta-like ligands, induces T-lineage differentiation and inhibits B-cell and myeloid development
  • unexpected functional similarity between JAG2 and the Delta-like ligands
  • hypoxic induction of JAG2 in tumor cells mediates a hypoxia-regulated cross-talk between tumor and endothelial cells
  • JAG2 is a key regulator of the timely and ordered generation of two of the defining cell types in the spinal cord, motor neurons (MNs) and oligodendrocyte progenitors (OLPs)
  • enhances immunomodulatory activity in adipose derived mesenchymal stem cells
  • JAG2 implicated in promoting aggressiveness of colorectal cancer (CRC)
  • JAG2 is involved in the regulation of migration and invasion of colon cancer cells without affecting cell proliferation
  • involved in the regulation of migration and invasion independent of the canonical NoTCH1 signaling pathway
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text inner ear
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for NOTCH1 (acts synergistically with DLL1, to regulate hair cell development in the mammalian inner ear)
  • interacting with IRF6 (IRF6 and JAG2 function in convergent molecular pathways during development of the oral ectoderm)
  • weaker NOTCH1-activator compared with the Delta-like ligands, revealing a NOTCH1 specific signal strength hierarchy for mammalian NOTCH ligands
  • BACE1 can effectively shed the membrane-anchored signaling molecule JAG1 but BACE1 fails to cleave JAG2
  • YAP1 activates JAG2 expression in muscle fibers, which in turn regulates the pool of fetal muscle progenitors via NOTCH1 in a non-cell-autonomous manner
  • cell & other
    REGULATION
    activated by transcriptionally activated by hypoxia in a HIF-1a dependent manner
    ASSOCIATED DISORDERS
    corresponding disease(s) LGMDR27
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in malignant plasma cells from multiple myeloma
    constitutional     --over  
    significantly increased in the colorectal cancer cell lines compared with that of normal colorectal cell line
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • high JAG2 expression may be useful as additional marker to identify aggressive Medulloblastoma (MB)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    therapeutic target for the treatment of colorectal cancer
    ANIMAL & CELL MODELS