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FLASH GENE
Symbol EPHB6 contributors: np/ - updated : 09-03-2007
HGNC name EPH receptor B6
HGNC id 3396
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a vestigial Ig-l domain
  • a protein kinase domain
  • a SAM (sterile alpha motif) domain
  • a single cysteine rich region and two FNIII domains in the extracellular region
    • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • ephrin receptor
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in short-range contact-mediated axonal guidance
  • can both positively and negatively regulate cell adhesion and migration
  • transduces signals to the nucleus and alters relevant gene expression, resulting in the decrease of invasiness of breast carcinoma cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ephrins B6 binding
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    silenced in invasive breast carcinoma cells
    tumoral     --over  
    in low stage neuroblastoma with NTRK1 high expression
    tumoral     --low  
    in melanoma in progression to metastatic disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    therapeutic approaches in melanoma
    ANIMAL & CELL MODELS