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FLASH GENE

Symbol

EPHB6

contributors: np/ - updated : 09-03-2007

HGNC name	EPH receptor B6
HGNC id	3396

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004445 20 - 4044 NP_004436 110.5 1021 - -

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune tonsils       highly Nervous nerve       highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a vestigial Ig-l domain
	a protein kinase domain
	a SAM (sterile alpha motif) domain
	a single cysteine rich region and two FNIII domains in the extracellular region

HOMOLOGY

Homologene

FAMILY	protein kinase superfamily
	Tyr protein kinase family
	ephrin receptor

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in short-range contact-mediated axonal guidance
	can both positively and negatively regulate cell adhesion and migration
	transduces signals to the nucleus and alters relevant gene expression, resulting in the decrease of invasiness of breast carcinoma cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ephrins B6 binding

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         silenced in invasive breast carcinoma cells tumoral     --over   in low stage neuroblastoma with NTRK1 high expression tumoral     --low   in melanoma in progression to metastatic disease

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer skin   therapeutic approaches in melanoma

ANIMAL & CELL MODELS