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FLASH GENE
Symbol NCAPH contributors: mct - updated : 25-06-2019
HGNC name non-SMC condensin I complex, subunit H
HGNC id 1112
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila barr locus product
Homologene
FAMILY
  • barr gene family
  • CND2 (condensin subunit 2) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in sister chromatid separation and modulation of topoisomerase II
  • essential for the structural integrity of centromeric heterochromatin during mitosis
  • regulatory subunit of the non-structural maintenance of chromosomes condensin I complex
    • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • topoisomerase II
  • interacting with PARP1 (role in single-strand break damage repair)
  • CASP3-mediated degradation of condensin NCAPH regulates mitotic cell death
  • interacting with DICER1 and DDX3X (DDX3X and DICER1 are required in promoting chromosome segregation and chromosomal localization of NCAPH
    • cell & other
    REGULATION
    Other degraded by CASP3 (Caspase-3-mediated degradation of NCAPH regulates mitotic cell death)
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH23
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    is associated with poor survival of patients with Prostate carcinoma
    tumoral     --over  
    in colorectal cancer cell lines comparing with normal human colonic epithelial cells
    constitutional        
    results in the loss of condensin I complex at the chromosomes, thus affecting the integrity of the chromosomes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    therapeutic target in Prostate carcinoma
    ANIMAL & CELL MODELS