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FLASH GENE
Symbol NCAPH contributors: mct - updated : 25-06-2019
HGNC name non-SMC condensin I complex, subunit H
HGNC id 1112
DNA
TYPE functioning gene
STRUCTURE 41.33 kb     18 Exon(s)
MAPPING cloned Y linked   status provisional
Map cen - D2S113 - NCAPH - D2S187 - D2S2311 - qter
Authors Cabello (97)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 4495 - 741 - 2016 27737959
18 - 5997 - 730 - 2016 27737959
18 - 5958 - 717 - 2016 27737959
17 - 5777 - 605 - 2016 27737959
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Endocrinepancreas   highly
Reproductivefemale systemuterus  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila barr locus product
Homologene
FAMILY
  • barr gene family
  • CND2 (condensin subunit 2) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in sister chromatid separation and modulation of topoisomerase II
  • essential for the structural integrity of centromeric heterochromatin during mitosis
  • regulatory subunit of the non-structural maintenance of chromosomes condensin I complex
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • topoisomerase II
  • interacting with PARP1 (role in single-strand break damage repair)
  • CASP3-mediated degradation of condensin NCAPH regulates mitotic cell death
  • interacting with DICER1 and DDX3X (DDX3X and DICER1 are required in promoting chromosome segregation and chromosomal localization of NCAPH
  • cell & other
    REGULATION
    Other degraded by CASP3 (Caspase-3-mediated degradation of NCAPH regulates mitotic cell death)
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH23
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    is associated with poor survival of patients with Prostate carcinoma
    tumoral     --over  
    in colorectal cancer cell lines comparing with normal human colonic epithelial cells
    constitutional        
    results in the loss of condensin I complex at the chromosomes, thus affecting the integrity of the chromosomes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    therapeutic target in Prostate carcinoma
    ANIMAL & CELL MODELS