SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic
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| intracellular,nuclear envelope
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| basic FUNCTION
| involved in the biosynthesis of membrane phosphoinositides |
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phosphorylating phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5-trisphosphate (PIP) |
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may regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation |
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involved in in the regulation of ERK1/2 signaling and inflammatory reactions in mast cells, with FREQ |
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PI4KB, EEF1A2 and PI(4)P likely play an important role in mammary neoplasia and acinar development  |
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dynamic association of the lipid kinase PI4KB with lysosomes (Lys), having regulatory function in lysosomal export and retrieval (pMID: 23258225) |
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PI4KB likely plays a role in breast oncogenesis and cooperation between RAB11A and PI4KB represents a novel AKT1 activation pathway |
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is involved in the regulated local synthesis of phospholipids that are crucial for trans-Golgi network (TGN)-to-plasma membrane trafficking |
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PI4KB is one of four PI4K enzymes that generate phosphatidylinositol 4-phosphate (PI4P), a minor but essential regulatory lipid found in all eukaryotic cells |
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is a key enzyme of the Golgi system because it produces its lipid hallmark - the phosphatidylinositol 4-phosphate (PI4P) |
