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FLASH GENE

Symbol

PI4KB

contributors: mct - updated : 11-03-2019

HGNC name	phosphatidylinositol 4-kinase, catalytic, beta
HGNC id	8984

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       highly   pancreas exocrine       moderately Endocrine adrenal gland       moderately   neuroendocrine pituitary     predominantly   thyroid       highly Lymphoid/Immune lymph node       highly   thymus       moderately Reproductive female system uterus     highly   female system breast mammary gland   moderately   female system ovary     highly   male system prostate     highly   male system testis     moderately Respiratory lung       moderately   respiratory tract larynx     highly Skin/Tegument skin       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately Connective adipose     moderately Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a PI3K/PI4K domain

HOMOLOGY

interspecies	homolog to rattus Pik4cb (97.7 pc)
	homolog to murine Pik4cb (98.5 pc)

Homologene

FAMILY

PI3/PI4-kinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytosolic
	intracellular,nuclear envelope

basic FUNCTION	involved in the biosynthesis of membrane phosphoinositides
	phosphorylating phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5-trisphosphate (PIP)
	may regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation
	involved in in the regulation of ERK1/2 signaling and inflammatory reactions in mast cells, with FREQ
	PI4KB, EEF1A2 and PI(4)P likely play an important role in mammary neoplasia and acinar development
	dynamic association of the lipid kinase PI4KB with lysosomes (Lys), having regulatory function in lysosomal export and retrieval (pMID: 23258225)
	PI4KB likely plays a role in breast oncogenesis and cooperation between RAB11A and PI4KB represents a novel AKT1 activation pathway
	is involved in the regulated local synthesis of phospholipids that are crucial for trans-Golgi network (TGN)-to-plasma membrane trafficking
	PI4KB is one of four PI4K enzymes that generate phosphatidylinositol 4-phosphate (PI4P), a minor but essential regulatory lipid found in all eukaryotic cells
	is a key enzyme of the Golgi system because it produces its lipid hallmark - the phosphatidylinositol 4-phosphate (PI4P)

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

endocytosis transport

text	receptor mediated endocytosis

PATHWAY

metabolism

lipid/lipoprotein

signaling

signal transduction

phosphatidylinositol biosynthesis

a component

INTERACTION

DNA

RNA

small molecule

protein	CALN1 and CABP7 physically associate with PI4KB, inhibit the enzyme profoundly at resting and low calcium levels, and negatively interfere with Golgi-to-plasma membrane trafficking
	unique role for CABP7 and CALN1 in the regulation of PI4KB
	ACBD3 is capable of recruiting PI4KB to membranes , and membrane recruitment of PI4KB by ACBD3 increases its enzymatic activity
	PI4KB interacted preferentially with the VHS domain of GGA2 compared with VHS domains of GGA1 and GGA3
	conserved role for GGA1, GGA2, GGA3 proteins in regulating phosphatidylinositol 4-kinase function at the TGN
	RAB30 having ability to recruit PI4KB (phosphatidylinositol 4-kinase beta) to the Golgi apparatus and GAS-containing autophagosome-like vacuoles (GcAVs)

cell & other

REGULATION

inhibited by

wortmannin

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS