| protein
| MAPK, blocks MAPK, phosphorylation by inhibiting the phosphorylation of IRS1 (down regulation of cyclin D1) |
|
PI3K/AKT implicating cell death and/or cell cycle arrest |
|
stimulating TNFSF10 through FOXO3 activation |
|
interacting with STK11 |
|
negative regulator of the PI3K pathway, that is a key downstream target of NEDD4 (NEDD4-regulated PTEN is a key regulator of terminal arborization) |
|
interacting with EGR1 (EGR1–PTEN network was found to influence synovial sarcoma cell survival, showing that SS18–SSX-mediated attenuation of this pathway enables these cells to escape cell death) |
|
SEMA4D/PLXNB1 promotes the dephosphorylation and activation of PTEN through the RRas GAP activity, inducing growth cone collapse |
|
association between PTEN and DLG4, association that requires the PDZ motif at the PTEN C-terminus |
|
CREB1 is a protein target of PTEN phosphatase and PTEN deficiency leads to CREB1 phosphorylation independent of the PI3K/AKT pathway (MID: 21385900) |
|
PTEN interacts with metal-responsive transcription factor 1 and stimulates its transcriptional activity |
|
novel role of PTEN in regulating stress response through modulating the PPP1R15B/EIF2S1 pathway |
|
PPARD regulates the expression of PTEN at the transcriptional level |
|
MIR29B is an upstream molecule of PTEN (regulates PTEN gene expression through downregulating DNMTS expression and subsequently induces hypomethylation in PTEN promoter |
|
PI3K/PTEN pathway plays an important role in the translocation of TRPC6 to the plasma membrane and may thus have a significant impact on Ca2+ signaling in cells that endogenously express TRPC6 |
|
posttranslational regulatory network in which the PTEN and FBXW7 pathways appear to converge on the regulation of Aurora-A level |
|
CBLB inhibits T cell activation by suppressing PTEN inactivation independently of its ubiquitin ligase activity |
|
PTEN secretion in exosomes required NDFIP1, an adaptor protein for members of the NEDD4 family of E3 ubiquitin ligases |
|
PTEN and PIKFYVE are two major players in phagosomal PtdIns(3)P metabolism |
|
PPP1R10 directly interacted with the lipid-binding domain (C2 domain) of PTEN and sequestered it in the nucleus |
|
might act as a negative regulator of NCOA3 whereby the association of PTEN with NCOA3 and FBXW7 could lead to the downregulation of NCOA3 transcriptional activity |
|
PBK and PTEN are new players in CHFR mediated mitotic checkpoint |
|
nuclear/chromatin PTEN mediates DNA damage repair through interacting with and modulating the activity of RAD52 |
|
chromatin PTEN is involved in DNA damage response partly through regulating RAD52 sumoylation |
|
nuclear trafficking of PTEN required both RAB5A as well as the E3 ligase adaptor protein NDFIP1 |
|
ERBB2, MYC, WIF1, RBM38, PTEN, are involved in the HOTAIR regulation network |
|
OTUD3 is a deubiquitylase of PTEN |
|
expression of PTEN, the primary negative regulator of PI3K/Akt, was significantly reduced in MEF2D-deficient cardiomyocytes and found to be a direct target gene of MEF2D |
|
PTEN is physically associated with a decatenation enzyme TOP2A and PTEN influences its stability through OTUD3 deubiquitinase |
|
PARL genetically interact and process PTEN-induced putative kinase a protein known for its critical role in mitochondrial homeostasis |
|
reciprocal regulation of PREX2 by PTEN whereby loss of PTEN results in a dramatic increase in expression of PREX2 at the protein level |
|
PTEN regulates spindle pole movement through DLG1-mediated recruitment of KIF11 to centrosomes |
|
functional interplay between PTEN and KIF11 in controlling mitotic spindle structure and chromosome behaviour during mitosis |
|
PTEN, INPP5J and INPP4B distinctly regulate PtdIns(3,4,5)P3 signalling downstream of PI3K and dysregulation of these phosphatases affects cancer outcomes |
|
protein phosphatase activity of PTEN dephosphorylates and inhibits autophosphorylated PGK1, thereby inhibiting glycolysis, ATP production, and brain tumor cell proliferation |
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
| insertion
|
|
| |
insertion/deletion in endometrial carcinomas, deletion in thyroid cancers (or transient ectopic expression) | | constitutional
| germinal mutation
|
|
|
| |
in PTEN-hamartoma syndrome (Proteus-Proteus-like syndrome, Bannayan and Cowden syndrome), and in VATER association with hydrocephaly | | tumoral
|
| LOH
|
|
| |
in hepatocellular carcinoma | | tumoral
|
|
|
| loss of function
| |
in hamartoma, glioma, uterus carcinoma | | tumoral
|
|
|
| loss of function
| |
in Bannayan and Cowden syndrome | | tumoral
| germinal mutation
|
|
|
| |
in Lhermitte-Duclos disease (LDD) , a rare cerebellar tumor associated with Cowden disease | | tumoral
|
|
|
| loss of function
| |
in deficient intestinal stem cells and initiate intestinal polyposis | | tumoral
|
|
| --low
|
| |
in melanomas | | constitutional
| germinal mutation
|
|
|
| |
heterozygous Arg234Gln in a patient with brain tumors of multiple lineages | | tumoral
|
| deletion
|
|
| |
Loss of PTEN and concomitant activation of AKTcould act in partnership with the TMPRSS2-ERG fusion protein to promote progression to prostatecancer | | tumoral
|
|
| --low
|
| |
loss of PTEN expression was an independent prognostic factor for poor overall survival in patients with stage II pancreatic ductal adenocarcinoma | | tumoral
|
|
| --other
|
| |
significant disruption of all three members of the PTEN-SLC9A3R1-PHLPP1 tumor suppressor network in high-grade glioma | |
