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FLASH GENE
Symbol NME4 contributors: mct - updated : 24-05-2006
HGNC name non-metastatic cells 4, protein expressed in
HGNC id 7852
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a mitochondrial targeting sequence
  • putative leucine-zipper domain
  • a Kpn (Drosophila Killer of prune) loop
  • a RGD domain and a C terminal extension preceded by the YEEEEP motifs
  • HOMOLOGY
    Homologene
    FAMILY nm23 nucleoside diphosphate kinase gene family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • peripheral membrane protein of the inner mitochondrial membrane with dual orientation toward the matrix and the intermembrane space
  • involved in the phosphorylation of nucleoside diphosphates
  • putatively involved int intramitochondrial GTP metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    nucleotide
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS