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FLASH GENE
Symbol NME4 contributors: mct - updated : 24-05-2006
HGNC name non-metastatic cells 4, protein expressed in
HGNC id 7852
Location 16p13      Physical location : 447.191 - 450.753
Genatlas name protein expressed in nucleoside diphosphate kinase
Synonym name nucleoside-diphosphate kinase 4
Synonym symbol(s) NM23-H4, NDKM, NDPK-D, NM23H4, nm23-H4
EC.number 2.7.4.6
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
 pharynx   highly
 stomach   highly
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a mitochondrial targeting sequence
  • putative leucine-zipper domain
  • a Kpn (Drosophila Killer of prune) loop
  • a RGD domain and a C terminal extension preceded by the YEEEEP motifs
    • HOMOLOGY
    Homologene
    FAMILY nm23 nucleoside diphosphate kinase gene family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • peripheral membrane protein of the inner mitochondrial membrane with dual orientation toward the matrix and the intermembrane space
  • involved in the phosphorylation of nucleoside diphosphates
  • putatively involved int intramitochondrial GTP metabolism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    nucleotide
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS