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FLASH GENE
Symbol LMAN1 contributors: mct/npt/pgu - updated : 11-05-2013
HGNC name lectin, mannose-binding, 1
HGNC id 6631
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one leguminous lectin-like domain
  • a luminal carbohydrate recognition domain (CRD) that binds to high-mannose-type oligosaccharides in a Ca2+-dependent manner
  • mono polymer dimer , hexamer
    HOMOLOGY
    interspecies homolog to murine Lman1
    intraspecies homolog to galectin
    Homologene
    FAMILY
  • family of leguminous type (L-type) lectins
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text type 1 membrane protein
    basic FUNCTION
  • involved in the transport of early processed glycoprotein from endoplasmic reticulum to Golgi
  • may facilitate glycoprotein transport with only low efficiency via its lectin function
  • membrane-bound lectin protein that cycles between the ER and Golgi
  • intracellular transport receptor of SERPINA1
  • LMAN1 and MCFD2 form a Ca(2+)-dependent cargo receptor that cycles between the endoplasmic reticulum (ER) and the ER-Golgi intermediate compartment for efficient transport of FV/FVIII from the ER to the Golgi
  • glycoprotein receptor, mediating transfer from the ER to the ER-Golgi intermediate compartment
  • with the co-receptor MCFD2, it transports coagulation factors V and VIII
  • central role of LMAN1 in regulating the binding in the ER and the subsequent release in the ERGIC of FV and FVIII
  • LMAN2, LMAN2L, LMAN1, participate in the vectorial transport of glycoproteins via sugar-protein interactions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with LMAN2L (overexpression of LMAN2L redistribute LMAN1 to the ER, suggesting interaction and functional interplay between these two lectins)
  • cargo receptor for the LDL receptor-related protein
  • interactions with PDI and TXNDC4 provide a novel, dynamic control of SUMF1 trafficking and enzymatic activity
  • MCFD2 bind both LMAN1 and the blood coagulation factors
  • binding to sugar is enhanced by its interaction with MCFD2, and defects in this interaction in F5F8D patients may be the cause for reduced secretion of factors V and VIII
  • may interact with LMAN2L in the ER, which may regulate the localization of LMAN1 inside cells
  • LMAN1 transports coagulation factors V (F5) and VIII (F8)
  • cell & other
    REGULATION
    induced by stress, tunicamycin and thapsigargin
    ASSOCIATED DISORDERS
    corresponding disease(s) FMFD2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS