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FLASH GENE
Symbol LMAN1 contributors: mct/npt/pgu - updated : 11-05-2013
HGNC name lectin, mannose-binding, 1
HGNC id 6631
DNA
TYPE functioning gene
STRUCTURE 31.45 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure promoter contains a single cis-acting element that mediates induction of the gene by thapsigargin and other ER stress-causing agents
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 4848 54.2 510 - 2007 17535801
  • a 30 aa signal peptide of 3.4 kda
  • a 480 aa signal peptide of 54.2 kda
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveesophagus   highly
    Endocrineparathyroid   highly
    Nervousbrain   moderately
    Reproductivemale systemprostate  moderately
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one leguminous lectin-like domain
  • a luminal carbohydrate recognition domain (CRD) that binds to high-mannose-type oligosaccharides in a Ca2+-dependent manner
  • mono polymer dimer , hexamer
    HOMOLOGY
    interspecies homolog to murine Lman1
    intraspecies homolog to galectin
    Homologene
    FAMILY
  • family of leguminous type (L-type) lectins
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text type 1 membrane protein
    basic FUNCTION
  • involved in the transport of early processed glycoprotein from endoplasmic reticulum to Golgi
  • may facilitate glycoprotein transport with only low efficiency via its lectin function
  • membrane-bound lectin protein that cycles between the ER and Golgi
  • intracellular transport receptor of SERPINA1
  • LMAN1 and MCFD2 form a Ca(2+)-dependent cargo receptor that cycles between the endoplasmic reticulum (ER) and the ER-Golgi intermediate compartment for efficient transport of FV/FVIII from the ER to the Golgi
  • glycoprotein receptor, mediating transfer from the ER to the ER-Golgi intermediate compartment
  • with the co-receptor MCFD2, it transports coagulation factors V and VIII
  • central role of LMAN1 in regulating the binding in the ER and the subsequent release in the ERGIC of FV and FVIII
  • LMAN2, LMAN2L, LMAN1, participate in the vectorial transport of glycoproteins via sugar-protein interactions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with LMAN2L (overexpression of LMAN2L redistribute LMAN1 to the ER, suggesting interaction and functional interplay between these two lectins)
  • cargo receptor for the LDL receptor-related protein
  • interactions with PDI and TXNDC4 provide a novel, dynamic control of SUMF1 trafficking and enzymatic activity
  • MCFD2 bind both LMAN1 and the blood coagulation factors
  • binding to sugar is enhanced by its interaction with MCFD2, and defects in this interaction in F5F8D patients may be the cause for reduced secretion of factors V and VIII
  • may interact with LMAN2L in the ER, which may regulate the localization of LMAN1 inside cells
  • LMAN1 transports coagulation factors V (F5) and VIII (F8)
  • cell & other
    REGULATION
    induced by stress, tunicamycin and thapsigargin
    ASSOCIATED DISORDERS
    corresponding disease(s) FMFD2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS