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FLASH GENE
Symbol KCNC4 contributors: mct - updated : 24-06-2014
HGNC name potassium voltage-gated channel, Shaw-related subfamily, member 4
HGNC id 6236
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six putative membrane-spanning domains
  • an hydrophobic pore including the P domain with the K+ channel signature, flanked by TM domains 5 and 6, sensitive to changes in membrane potential
  • a segment s4 is probably the voltage-sensor and characterized by a series of positively charged amino acids at every third position
  • a tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments
  • HOMOLOGY
    interspecies homolog to murine Kv3.4
    Homologene
    FAMILY Drosophila Shaw-related family
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION mediating the voltage-dependent potassium ion permeability of excitable membranes
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with KCNE3,altering its properties and restituting the attributes of the native channel in plasma membrane of skeletal muscle
  • cell & other
    REGULATION
    activated by BMP2 that significantly (>2-fold) upregulated mRNA expression of KCNC4
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS