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FLASH GENE

Symbol

KCNC4

contributors: mct - updated : 24-06-2014

HGNC name	potassium voltage-gated channel, Shaw-related subfamily, member 4
HGNC id	6236

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p21      Physical location : 110.753.335 - 110.776.674
Synonym symbol(s)	KV3.4, KSHIIIC, HKSHIIIC, MGC126818

DNA

TYPE	functioning gene
STRUCTURE	22.00 kb     5 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed V1 - - 3713 - 635 - Abbott V2 - - 1855 - 582 - Abbott V3 - - 3023 - 626 - Abbott

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly   pancreas       highly   parathyroid       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six putative membrane-spanning domains
	an hydrophobic pore including the P domain with the K+ channel signature, flanked by TM domains 5 and 6, sensitive to changes in membrane potential
	a segment s4 is probably the voltage-sensor and characterized by a series of positively charged amino acids at every third position
	a tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments

HOMOLOGY

interspecies

homolog to murine Kv3.4

Homologene

FAMILY

Drosophila Shaw-related family

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

mediating the voltage-dependent potassium ion permeability of excitable membranes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

associating with KCNE3,altering its properties and restituting the attributes of the native channel in plasma membrane of skeletal muscle

cell & other

REGULATION

activated by

BMP2 that significantly (>2-fold) upregulated mRNA expression of KCNC4

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS