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FLASH GENE
Symbol TRAM2 contributors: mct/npt - updated : 29-03-2010
HGNC name translocation associated membrane protein 2
HGNC id 16855
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal part of TRAM2 interacting with the Ca(2+) pump of the ER, SERCA2B
    • HOMOLOGY
    intraspecies homolog to TRAM1
    Homologene
    FAMILY
  • LASS1 family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in determining life span
  • playing a role in collagen type I expression in hepatic stellate cells (HSCs) and fibroblasts
  • required for the biosynthesis of type I collagen by coupling the activity of SERCA2b with the activity of the translocon
  • facilitates proper folding of type I collagen (Pregizer 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SERCA2B
  • interacting with RUNX2 (may regulate TRAM2 expression in a BMP-dependent manner, and TRAM2 may participate in the overall osteogenic function of RUNX2) (Pregizer 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS