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FLASH GENE
Symbol TRAM2 contributors: mct/npt - updated : 29-03-2010
HGNC name translocation associated membrane protein 2
HGNC id 16855
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousspinal cord    
Reproductivemale systemprostate   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal part of TRAM2 interacting with the Ca(2+) pump of the ER, SERCA2B
  • HOMOLOGY
    intraspecies homolog to TRAM1
    Homologene
    FAMILY
  • LASS1 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in determining life span
  • playing a role in collagen type I expression in hepatic stellate cells (HSCs) and fibroblasts
  • required for the biosynthesis of type I collagen by coupling the activity of SERCA2b with the activity of the translocon
  • facilitates proper folding of type I collagen (Pregizer 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SERCA2B
  • interacting with RUNX2 (may regulate TRAM2 expression in a BMP-dependent manner, and TRAM2 may participate in the overall osteogenic function of RUNX2) (Pregizer 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS