Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TOP2B contributors: mct - updated : 16-01-2016
HGNC name topoisomerase (DNA) II beta 180kDa
HGNC id 11990
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three functional domains associated with energy transduction, DNA-breakage reunion activity
  • a C terminal nuclear export signal (NLS), that determine its isoform-specific functions in proliferating cells
    • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Top2b (96.4 pc)
    Homologene
    FAMILY
  • type II topoisomerase family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • three different topoisomerases have been identified in mitochondria: TOP1MT, TOP3A and a truncated form of TOP2B
    • basic FUNCTION
  • acting as a DNA topoisomerase II
  • involved in the breakage and rejoining of double strand of DNA
  • relaxing both positively and negatively supercoiled DNA
  • target of several drugs, widely used in the treatment of human cancers
  • regulating differentiation
  • a critical role of TopIIbeta in neurite outgrowth
  • removes supercoils and catenanes generated during DNA metabolic processes such as transcription and replication
  • TOP2A is essential for cell proliferation, whereas TOP2B is required only for aspects of nerve growth and brain development
  • activates a subset of neuronal genes that are repressed in AT-rich genomic environment
  • involved in transcriptional activation of certain genes, which assumes accurate targeting of the enzyme to its action site
  • involved in the processes of neuronal differentiation, migration, axon guidance
  • involved in DNA strand break formation in elongating spermatids
  • required for lamina-specific targeting of retinal ganglion cell axons and dendrites
  • role, at least indirect, in the repair of ENU-mediated strand breaks via base excision repair pathway including the activities of uracil DNA-glycosylase (UDG) and ligase (LIG)
    • CELLULAR PROCESS cell life, differentiation
    nucleotide, replication
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ATPase component of the topoisomerase II
    • INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • associates stoichiometrically with HNRNPU in the presence of RNA
  • functional relationship between the DNA strand break-generating activity of TOP2B and the DNA strand break-dependent activation of PARP1 and PARP2 that in turn inhibit TOP2B
  • strong interaction with XRCC6 as well as PARP1 suggesting that TOP2B is associated both in XRCC6 and PARP-dependent pathways in DSBs repair in primary neurons
  • might be a down-stream target of NR4A2, which might influence the processes of axon genesis in dopaminergic neurons via the regulation of TOP2B expression
  • novel function of the BRCA1-BARD1 complex in the regulation of TOP2B and Pol II-mediated gene expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    in Top2b null mice, significant loss of dopaminergic neurons in the substantial nigra and lack of neurites along the nigro-striatal pathway