SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,nucleolus
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text
| three different topoisomerases have been identified in mitochondria: TOP1MT, TOP3A and a truncated form of TOP2B |
basic FUNCTION
| acting as a DNA topoisomerase II |
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involved in the breakage and rejoining of double strand of DNA |
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relaxing both positively and negatively supercoiled DNA |
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target of several drugs, widely used in the treatment of human cancers |
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regulating differentiation |
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a critical role of TopIIbeta in neurite outgrowth |
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removes supercoils and catenanes generated during DNA metabolic processes such as transcription and replication |
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TOP2A is essential for cell proliferation, whereas TOP2B is required only for aspects of nerve growth and brain development |
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activates a subset of neuronal genes that are repressed in AT-rich genomic environment |
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involved in transcriptional activation of certain genes, which assumes accurate targeting of the enzyme to its action site |
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involved in the processes of neuronal differentiation, migration, axon guidance |
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involved in DNA strand break formation in elongating spermatids |
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required for lamina-specific targeting of retinal ganglion cell axons and dendrites |
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role, at least indirect, in the repair of ENU-mediated strand breaks via base excision repair pathway including the activities of uracil DNA-glycosylase (UDG) and ligase (LIG) |