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FLASH GENE
Symbol HOXD10 contributors: npt/mct - updated : 17-12-2009
HGNC name homeobox D10
HGNC id 5133
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal portion of the activation domain contains several consensus sequence elements also found in other mammalian AbdB family genes
  • helix-turn-helix, DNA binding domain
    • HOMOLOGY
    interspecies homolog to murine Hox-4.5
    Homologene
    FAMILY
  • Abd-B homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in limb morphogenesis
  • may play a continuing role in adult genitourinary tract function (Redline 1992)
  • has tumor-suppressive functions for mammary epithelial cells (Carrio 2005)
  • positively regulating microRNA-7 (miR-7) (Reddy 2008)
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with HOXD9 (cross-regulatory interactions between these genes might be essential for their proper expression) (Zappavigna 1991)
    cell & other
    REGULATION
    repressed by HOXD11 (HOXD11 suppresses the expression of HOXD10 and the retinoic acid synthetic enzyme, retinaldehyde dehydrogenase 2 RALDH2) (Misra 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s) PSDY2 , CVT
    Susceptibility isolated congenital vertical talus
    Variant & Polymorphism other M319K mutation in a family with isolated congenital vertical talus (Dobbs 2006)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS