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FLASH GENE

Symbol

HOXD10

contributors: npt/mct - updated : 17-12-2009

HGNC name	homeobox D10
HGNC id	5133

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
STRUCTURE	3.18 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see HOXD@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002148 2 - 1814 NP_002139 - 340 - Redline (1992)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol   reproductive tract       predominantly Nervous brain         Reproductive female system uterus     highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	developing limb buds

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal portion of the activation domain contains several consensus sequence elements also found in other mammalian AbdB family genes
	helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies

homolog to murine Hox-4.5

Homologene

FAMILY

Abd-B homeobox family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	playing a role in limb morphogenesis
	may play a continuing role in adult genitourinary tract function (Redline 1992)
	has tumor-suppressive functions for mammary epithelial cells (Carrio 2005)
	positively regulating microRNA-7 (miR-7) (Reddy 2008)

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with HOXD9 (cross-regulatory interactions between these genes might be essential for their proper expression) (Zappavigna 1991)

cell & other

REGULATION

repressed by

HOXD11 (HOXD11 suppresses the expression of HOXD10 and the retinoic acid synthetic enzyme, retinaldehyde dehydrogenase 2 RALDH2) (Misra 2009)

ASSOCIATED DISORDERS

corresponding disease(s)

PSDY2 , CVT

Susceptibility

isolated congenital vertical talus

Variant & Polymorphism other	M319K mutation in a family with isolated congenital vertical talus (Dobbs 2006)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS