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FLASH GENE
Symbol TBC1D8B contributors: mct - updated : 20-03-2019
HGNC name TBC1 domain family member 8B
HGNC id 24715
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal EF-hand domain
    • HOMOLOGY
    Homologene
    FAMILY TBC domain protein family (Tre-2/Bub2/CDC16)
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • Rab-GTPase-activating protein likely involved in endocytic and recycling pathways 0)
  • crucial role of TBC1D8B in the cellular recycling processes, probably as a RAB11B GTPase-activating protein 0)
  • TBC1D8B is a specific RAB11B-GTPase activating protein 0)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between TBC1D8B and RAB11B, a key protein in vesicular recycling in cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SRN7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS