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FLASH GENE
Symbol TBC1D8B contributors: mct - updated : 20-03-2019
HGNC name TBC1 domain family member 8B
HGNC id 24715
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Urinarypodocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal EF-hand domain
    • HOMOLOGY
    Homologene
    FAMILY TBC domain protein family (Tre-2/Bub2/CDC16)
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • Rab-GTPase-activating protein likely involved in endocytic and recycling pathways 0)
  • crucial role of TBC1D8B in the cellular recycling processes, probably as a RAB11B GTPase-activating protein 0)
  • TBC1D8B is a specific RAB11B-GTPase activating protein 0)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between TBC1D8B and RAB11B, a key protein in vesicular recycling in cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SRN7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS