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FLASH GENE

Symbol

VWCE

contributors: mct/npt - updated : 20-04-2010

HGNC name	von Willebrand factor C and EGF domains
HGNC id	26487

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	may be a regulatory element in the beta-catenin signaling pathway (Lian 2006)
	potential role in hypoxia-induced renal tubular epithelial-to-mesenchymal (EMT) (Du 2010)
	mediates hypoxia-induced EMT through the suppression of CDH1 and the activation of the beta-catenin/TCF pathway (Du 2010)
	may be involved in hypoxia-induced renal fibrosis, and hypoxia responsive factor that is critical for the induction of EMT in renal tubular cells (Du 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	may be a target for chemoprevention of hepatocellular carcinoma (Lian 2006)

ANIMAL & CELL MODELS