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FLASH GENE
Symbol VWCE contributors: mct/npt - updated : 20-04-2010
HGNC name von Willebrand factor C and EGF domains
HGNC id 26487
Location 11q12.2      Physical location : 61.025.758 - 61.062.788
Synonym name
  • upregulated gene 11
  • HBxAg up-regulated gene 11 protein
  • HBV X protein up-regulated gene 11 protein
    • Synonym symbol(s) FLJ32009, URG11, VWC1
    DNA
    TYPE functioning gene
    STRUCTURE 37.03 kb     20 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 3536 - 955 - Du (2010)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be a regulatory element in the beta-catenin signaling pathway (Lian 2006)
  • potential role in hypoxia-induced renal tubular epithelial-to-mesenchymal (EMT) (Du 2010)
  • mediates hypoxia-induced EMT through the suppression of CDH1 and the activation of the beta-catenin/TCF pathway (Du 2010)
  • may be involved in hypoxia-induced renal fibrosis, and hypoxia responsive factor that is critical for the induction of EMT in renal tubular cells (Du 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target may be a target for chemoprevention of hepatocellular carcinoma (Lian 2006)
    ANIMAL & CELL MODELS