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FLASH GENE
Symbol L3HYPDH contributors: mct - updated : 21-09-2017
HGNC name trans-L-3-hydroxyproline dehydratase [Homo sapiens
HGNC id 20488
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • lack a specific cysteine residue that is known to be critical for racemase activity, but contain a threonine residue at this position
    • HOMOLOGY
    Homologene
    FAMILY
  • proline racemase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • presumably, serves to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins that contain this amino acid, such as collagen IV, which is an important structural component of basement membrane
  • is also the first human enzyme that acts on trans-3-hydroxy-L-proline
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS