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FLASH GENE
Symbol L3HYPDH contributors: mct - updated : 21-09-2017
HGNC name trans-L-3-hydroxyproline dehydratase [Homo sapiens
HGNC id 20488
Location 14q23.1      Physical location : -
Synonym name
  • hypothetical protein LOC112849
  • probable proline racemase
  • chromosome 14 open reading frame 149
  • Synonym symbol(s) FLJ25436, C14orf149
    EC.number 4.2.1.77
    DNA
    TYPE functioning gene
    STRUCTURE 18.89 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1381 38 354 - 2012 22528483
    - - 1510 - 183 - 2012 22528483
    - - 920 - 183 - 2012 22528483
    - - 4159 - 337 - 2012 22528483
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • lack a specific cysteine residue that is known to be critical for racemase activity, but contain a threonine residue at this position
  • HOMOLOGY
    Homologene
    FAMILY
  • proline racemase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • presumably, serves to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins that contain this amino acid, such as collagen IV, which is an important structural component of basement membrane
  • is also the first human enzyme that acts on trans-3-hydroxy-L-proline
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS