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FLASH GENE
Symbol SDHAF2 contributors: npt/ - updated : 08-07-2008
HGNC name succinate dehydrogenase complex assembly factor 2
HGNC id 26034
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • EMI5 family
    • CATEGORY enzyme , unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • may be involved in the flavination of succinate dehydrogenase (Hao 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the catalytic subunit of the succinate dehydrogenase (SDH) complex (Hao 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PGL2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in paraganglioma (Hao 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • tumor susceptibility gene (segregate with disease in a family with hereditary paraganglioma (Hao 2009)
    • Marker
    Therapy target
    ANIMAL & CELL MODELS