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FLASH GENE
Symbol SDHAF2 contributors: npt/ - updated : 08-07-2008
HGNC name succinate dehydrogenase complex assembly factor 2
HGNC id 26034
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Endocrineparathyroid    
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • EMI5 family
    • CATEGORY enzyme , unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • may be involved in the flavination of succinate dehydrogenase (Hao 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the catalytic subunit of the succinate dehydrogenase (SDH) complex (Hao 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PGL2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in paraganglioma (Hao 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • tumor susceptibility gene (segregate with disease in a family with hereditary paraganglioma (Hao 2009)
    • Marker
    Therapy target
    ANIMAL & CELL MODELS