SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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basic FUNCTION
| involved in the regulation of progression through cell cycle |
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phosphorylating glucose to produce glucose-6-phosphate |
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induction may participate in hepatocellular carcinomas progression |
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promotes neuronal survival and acts downstream of glycogen synthase kinase-3 |
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acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration |
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glycolytic enzyme hexokinase 2 (HK2) is crucial for the Warburg effect in human glioblastoma multiforme (GBM), the most common malignant brain tumor |
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HK2 is required for tumor initiation and maintenance |
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HK2 plays important roles in glycolysis regulation and in cell cycle checkpoint activation |
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HK2 functions likely as a molecular switch from glycolysis to autophagy to ensure cellular energy homeostasis under starvation conditions |
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HK2 was required for the lung cancer cell growth |
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plays a pivotal role in the glycolytic pathway |
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plays important roles in the glycolytic, proliferation and migration properties of colorectal carcinoma |