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FLASH GENE
Symbol NOL7 contributors: mct - updated : 06-01-2015
HGNC name nucleolar protein 7, 27kDa
HGNC id 21040
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Nol7 (77.7pc)
homolog to rattus Nol7 (81.5pc)
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,nucleus,nucleoplasm
intracellular,nucleus,nucleolus
text
  • mRNA-binding protein that must localize to the nucleoplasm to exert its antiangiogenic and tumor suppressive effects
    • basic FUNCTION
  • playing a role in antiangiogenic activity (Hasina 2006)
  • may function as a TSG in part by modulating the expression of the angiogenic phenotype
  • may function in both the nucleus and nucleolus
  • is important for maintaining internal nucleolar structure and cell growth rates, and while specific protein localization can be obtained by specific short localization motifs, nucleolar residency through binding must be mediated by a synergistic combination of protein modules
  • significantly alters THBS1 expression and may be a master regulator that coordinates the post-transcriptional expression of key signaling factors critical for the regulation of the angiogenic phenotype
  • tumor suppressor, acts as a master regulator of angiogenesis by downregulating pro-angiogenic factors and upregulating anti-angiogenic factors
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • tumor suppressor that induces an antiangiogenic phenotype and suppresses tumor growth, in part through upregulation of THBS1
  • RB1 positively regulates NOL7 at the transcriptional level by recruiting transcription factors and transcription machinery proteins to its promoter region
    • cell & other
    REGULATION
    induced by c-Myc and RXRalpha (Mankame 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in cervical cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS