basic FUNCTION
| playing a role in antiangiogenic activity (Hasina 2006) |
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may function as a TSG in part by modulating the expression of the angiogenic phenotype |
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may function in both the nucleus and nucleolus |
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is important for maintaining internal nucleolar structure and cell growth rates, and while specific protein localization can be obtained by specific short localization motifs, nucleolar residency through binding must be mediated by a synergistic combination of protein modules |
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significantly alters THBS1 expression and may be a master regulator that coordinates the post-transcriptional expression of key signaling factors critical for the regulation of the angiogenic phenotype |
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tumor suppressor, acts as a master regulator of angiogenesis by downregulating pro-angiogenic factors and upregulating anti-angiogenic factors |