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FLASH GENE
Symbol NOL7 contributors: mct - updated : 06-01-2015
HGNC name nucleolar protein 7, 27kDa
HGNC id 21040
DNA
TYPE functioning gene
STRUCTURE 5.57 kb     8 Exon(s)
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • essential elements required for the optimal promoter activity of NOL7 560bp upstream of the translation start site
  • potential binding sites for the SP1, c-Myc and RXRalpha transcription factors
  • promoter region possesses each of the key elements of a TATA-less promoter
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 896 29 257 localized to the nucleolus 2011 21818416
  • NOL7-SP1 long form
  • confined to the nucleolar granular component, and during cell division disassociated from the nucleolus
  • - - - - - nucleoplasmic 2011 21818416
    - - - - - distributed throughout the whole cell 2011 21818416
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineadrenal gland   highly
     thyroid   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Nol7 (77.7pc)
    homolog to rattus Nol7 (81.5pc)
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • mRNA-binding protein that must localize to the nucleoplasm to exert its antiangiogenic and tumor suppressive effects
  • basic FUNCTION
  • playing a role in antiangiogenic activity (Hasina 2006)
  • may function as a TSG in part by modulating the expression of the angiogenic phenotype
  • may function in both the nucleus and nucleolus
  • is important for maintaining internal nucleolar structure and cell growth rates, and while specific protein localization can be obtained by specific short localization motifs, nucleolar residency through binding must be mediated by a synergistic combination of protein modules
  • significantly alters THBS1 expression and may be a master regulator that coordinates the post-transcriptional expression of key signaling factors critical for the regulation of the angiogenic phenotype
  • tumor suppressor, acts as a master regulator of angiogenesis by downregulating pro-angiogenic factors and upregulating anti-angiogenic factors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • tumor suppressor that induces an antiangiogenic phenotype and suppresses tumor growth, in part through upregulation of THBS1
  • RB1 positively regulates NOL7 at the transcriptional level by recruiting transcription factors and transcription machinery proteins to its promoter region
  • cell & other
    REGULATION
    induced by c-Myc and RXRalpha (Mankame 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in cervical cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS