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FLASH GENE
Symbol NUP35 contributors: mct - updated : 16-05-2014
HGNC name nucleoporin 35kDa
HGNC id 29797
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a small number of scattered phenylalanine-glycine repeats, but not the large domains seen in other nucleoporins
  • highly conserved region containing an RNA-recognition motif (RRM) domain
    • HOMOLOGY
    interspecies ortholog to S. cerevisiae Nup53p
    Homologene
    FAMILY nucleoporin family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • required for nuclear envelope and nuclear pore complex assembly
  • has an evolutionary conserved role in nuclear envelope formation and function, and this role is particularly critical during the rapid cell divisions of early embryogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the nuclear pore complex
  • formation of a NUP35-NUP155 complex plays a critical role in the processes of nuclear envelope (NE) and nuclear pore complexes assembly
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • potential functional link between TMEM48 and the soluble nucleoporins NUP93, NUP35, and NUP205
  • interact with NUP93, NUP155 and NUP205
  • interaction between NUP35 and the integral pore membrane protein NDC1 is essential for vertebrate nuclear pore complexes (NPCs) assembly
  • interaction of NUP35 and NUP155 has a crucial role in NPC formation as the main determinant of recruitment of NUP155 to the assembling pore
  • self-interaction between the N- and C-terminal domains of NUP155 has an auto-inhibitory function that prevents interaction between the N terminus of NUP155 with the C-terminal region of NUP35
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS