Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NUP35 contributors: mct - updated : 16-05-2014
HGNC name nucleoporin 35kDa
HGNC id 29797
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1649 - 326 - 2005 15703211
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Nervousnerve   highly
Reproductivemale systemtestis  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a small number of scattered phenylalanine-glycine repeats, but not the large domains seen in other nucleoporins
  • highly conserved region containing an RNA-recognition motif (RRM) domain
  • HOMOLOGY
    interspecies ortholog to S. cerevisiae Nup53p
    Homologene
    FAMILY nucleoporin family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • required for nuclear envelope and nuclear pore complex assembly
  • has an evolutionary conserved role in nuclear envelope formation and function, and this role is particularly critical during the rapid cell divisions of early embryogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the nuclear pore complex
  • formation of a NUP35-NUP155 complex plays a critical role in the processes of nuclear envelope (NE) and nuclear pore complexes assembly
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • potential functional link between TMEM48 and the soluble nucleoporins NUP93, NUP35, and NUP205
  • interact with NUP93, NUP155 and NUP205
  • interaction between NUP35 and the integral pore membrane protein NDC1 is essential for vertebrate nuclear pore complexes (NPCs) assembly
  • interaction of NUP35 and NUP155 has a crucial role in NPC formation as the main determinant of recruitment of NUP155 to the assembling pore
  • self-interaction between the N- and C-terminal domains of NUP155 has an auto-inhibitory function that prevents interaction between the N terminus of NUP155 with the C-terminal region of NUP35
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS