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FLASH GENE
Symbol REEP3 contributors: mct - updated : 06-04-2016
HGNC name receptor accessory protein 3
HGNC id 23711
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
common domain REEP5/DP, and HVA22
HOMOLOGY
Homologene
FAMILY DP1 family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,cytoskeleton,microtubule
basic FUNCTION
  • may enhance the cell surface expression of odorant receptors
  • REEP3/REEP4 function redundantly to clear the ER from metaphase chromatin, thereby ensuring correct progression through mitosis and proper nuclear envelope architecture.
  • membrane shaping adapter protein that modulate specific G protein-coupled receptor trafficking by affecting ER cargo capacity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with odorant receptor proteins
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for autism
    Marker
    Therapy target
    ANIMAL & CELL MODELS