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FLASH GENE
Symbol REEP3 contributors: mct - updated : 06-04-2016
HGNC name receptor accessory protein 3
HGNC id 23711
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
 thyroid   highly
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
common domain REEP5/DP, and HVA22
HOMOLOGY
Homologene
FAMILY DP1 family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,cytoskeleton,microtubule
basic FUNCTION
  • may enhance the cell surface expression of odorant receptors
  • REEP3/REEP4 function redundantly to clear the ER from metaphase chromatin, thereby ensuring correct progression through mitosis and proper nuclear envelope architecture.
  • membrane shaping adapter protein that modulate specific G protein-coupled receptor trafficking by affecting ER cargo capacity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with odorant receptor proteins
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for autism
    Marker
    Therapy target
    ANIMAL & CELL MODELS