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FLASH GENE
Symbol MARVELD3 contributors: mct/pgu - updated : 09-02-2013
HGNC name MARVEL domain containing 3
HGNC id 30525
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain like occludin and tricellulin
    • HOMOLOGY
    Homologene
    FAMILY
  • MARVEL domain family
  • tight junction-associated occludin family of transmembrane proteins
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,nucleus
    text
  • co-localises with occludin at tight junctions in intestinal and corneal epithelial cells
    • basic FUNCTION
  • tight junction-associated transmembrane protein of the occludin family
  • functions as a determinant of epithelial paracellular permeability properties
  • although it is able to partially compensate for occludin or tricellulin loss, it cannot fully restore function
  • MARVELD3, OCLN, and MARVELD2 are best considered as a group with both redundant and unique contributions to epithelial function and tight junction regulation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MARVELD3, OCLN, and MARVELD2 define the tight junction-associated MARVEL protein family
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OCLN, MARVELD3 and MARVELD2 exhibited homophilic cis-interactions, along one plasma membrane (claudins regulate the interactions between OCLN, MARVELD2 and MARVELD3, which, inversely, modulate claudin oligomerization)
    • cell & other
    REGULATION
    Other transcriptionally downregulated in SNAI1-induced EMT during the progression for the pancreatic cancer
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS