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FLASH GENE
Symbol MARVELD3 contributors: mct/pgu - updated : 09-02-2013
HGNC name MARVEL domain containing 3
HGNC id 30525
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine     Homo sapiensAdult
 stomach   highly
Endocrineparathyroid   highly
Reproductivefemale systembreastmammary gland highly
Visualeyeanterior segmentcornea   Homo sapiensAdult
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell Homo sapiensAdult
Visualepithelial cell Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain like occludin and tricellulin
  • HOMOLOGY
    Homologene
    FAMILY
  • MARVEL domain family
  • tight junction-associated occludin family of transmembrane proteins
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,nucleus
    text
  • co-localises with occludin at tight junctions in intestinal and corneal epithelial cells
  • basic FUNCTION
  • tight junction-associated transmembrane protein of the occludin family
  • functions as a determinant of epithelial paracellular permeability properties
  • although it is able to partially compensate for occludin or tricellulin loss, it cannot fully restore function
  • MARVELD3, OCLN, and MARVELD2 are best considered as a group with both redundant and unique contributions to epithelial function and tight junction regulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MARVELD3, OCLN, and MARVELD2 define the tight junction-associated MARVEL protein family
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OCLN, MARVELD3 and MARVELD2 exhibited homophilic cis-interactions, along one plasma membrane (claudins regulate the interactions between OCLN, MARVELD2 and MARVELD3, which, inversely, modulate claudin oligomerization)
  • cell & other
    REGULATION
    Other transcriptionally downregulated in SNAI1-induced EMT during the progression for the pancreatic cancer
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS